She has modeled in advertising for companies such as Reebok, Vidal Sassoon, Coors, Frederick's of Hollywood, Hanes, and Sunkist.She was Miss Makita Power Tools 1986 and did appearances at woodworking trade shows.In 2000 she has her own talk show The Cindy Margolis Show it presents each evening from Miami Beach.
This pictorial was held in conjunction with a competition where the winner would accompany Margolis to a party at the Playboy mansion. A portion of the sales of her issue went to her charity, the Cindy Margolis Get a Download of This Fertility Fund. She was very proud to have posed, stating: “ Me, of all people, the ultimate girl next door, the one who made it by not taking off her clothes.And now my crowning achievement is doing Playboy and being comfortable in my own skin. ” In spring 2006, Margolis was the winner of NBC's Celebrity Cooking Showdown.She appears briefly in Barker’s Beauties in 1995 and in the TV show The Price Is Right.She also plays a killer robot in the movie Austin Powers."It will be fun to go up against the 20-year-olds and show them that they don't have anything on me! A portion of the proceeds from the issues sold will go to a charity for which Margolis is a spokeswoman, "Resolve".
This charity aims to get fertility treatment better covered by insurance companies. Margolis posed for a second Playboy pictorial for the July 2008 issue.
At the peak of her popularity, images of Margolis were downloaded 70,000 times in a span of 24 hours.
In November 2005, Margolis teamed up with the World Poker Tour to become the new hostess for Chipleaders.
In the early 90s she was a model for many companies like Reebok, Vidal Sassoon, Coors, Frederick’s of Hollywood, Hanes and Sunkist.
It is diversifying its business model being swimsuit and out annual calendars. It begins in a show with Tim Robbins and Don Lapre.
Cindy Margolis dated and married to restaurateur Guy Starkman.